Organ distribution of erythropoietin messenger RNA in normal and uremic rats.

@article{Tan1991OrganDO,
  title={Organ distribution of erythropoietin messenger RNA in normal and uremic rats.},
  author={Chia Chi Tan and Kai Uwe Eckardt and Peter J Ratcliffe},
  journal={Kidney international},
  year={1991},
  volume={40 1},
  pages={69-76}
}
We used RNAase protection assays to measure low levels of erythropoietin messenger RNA (EPO mRNA) in the organs of unstimulated rats, and to compare basal and stimulated levels of EPO mRNA in the kidneys and extrarenal organs of rats rendered uremic by subtotal nephrectomy, with pair-fed controls. Using this sensitive assay, EPO mRNA was measured in the kidneys of unstimulated control animals and was detectable, at lower levels, in the liver and lung. After exposure to hypoxia, there was a 150… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 38 extracted citations

Similar Papers

Loading similar papers…