Organ culture of the trigeminal ganglion induces enhanced expression of calcitonin gene-related peptide via activation of extracellular signal-regulated protein kinase 1/2.

@article{Tajti2011OrganCO,
  title={Organ culture of the trigeminal ganglion induces enhanced expression of calcitonin gene-related peptide via activation of extracellular signal-regulated protein kinase 1/2.},
  author={J{\'a}nos Tajti and Anik{\'o} Kuris and L{\'a}szl{\'o} V{\'e}csei and Cang-Bao Xu and Lars Edvinsson},
  journal={Cephalalgia : an international journal of headache},
  year={2011},
  volume={31 1},
  pages={95-105}
}
  • János Tajti, Anikó Kuris, +2 authors Lars Edvinsson
  • Published 2011 in
    Cephalalgia : an international journal of…
  • DOI:10.1177/0333102410382796
BACKGROUND AND OBJECTIVE Clinical and experimental studies have revealed a central role of calcitonin gene-related peptide (CGRP) in primary headaches. The role of extracellular signal-regulated kinase 1 and 2 (ERK1/2) in neuronal and glial cell expression of CGRP- immunoreactivity (-ir) in rat trigeminal ganglia was studied with an organ culture method. EXPERIMENTAL PROCEDURES Sections of adult rat trigeminal ganglia were cultured for up to 48 hours, examined with immunohistochemistry and… CONTINUE READING

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