Organ-Specific Branching Morphogenesis

  title={Organ-Specific Branching Morphogenesis},
  author={Christine Michaela Lang and Lisa Conrad and Dagmar Iber},
  journal={Frontiers in Cell and Developmental Biology},
A common developmental process, called branching morphogenesis, generates the epithelial trees in a variety of organs, including the lungs, kidneys, and glands. How branching morphogenesis can create epithelial architectures of very different shapes and functions remains elusive. In this review, we compare branching morphogenesis and its regulation in lungs and kidneys and discuss the role of signaling pathways, the mesenchyme, the extracellular matrix, and the cytoskeleton as potential organ… 

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