Orf virus inhibits interferon stimulated gene expression and modulates the JAK/STAT signalling pathway.


Interferons (IFNs) play a critical role as a first line of defence against viral infection. Activation of the Janus kinase/signal transducer and activation of transcription (JAK/STAT) pathway by IFNs leads to the production of IFN stimulated genes (ISGs) that block viral replication. The Parapoxvirus, Orf virus (ORFV) induces acute pustular skin lesions of… (More)
DOI: 10.1016/j.virusres.2015.06.014

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