Orf virus-encoded interleukin-10 inhibits maturation, antigen presentation and migration of murine dendritic cells.

@article{Lateef2003OrfVI,
  title={Orf virus-encoded interleukin-10 inhibits maturation, antigen presentation and migration of murine dendritic cells.},
  author={Zabeen Lateef and Stephen B. Fleming and Gary M Halliday and Lee Faulkner and Andrew Mercer and Margaret A. Baird},
  journal={The Journal of general virology},
  year={2003},
  volume={84 Pt 5},
  pages={1101-9}
}
Orf virus (ORFV) belongs to the genus Parapoxvirus and induces cutaneous pustular lesions in sheep, goats and humans. ORFV is unusual in that it has the ability to reinfect its host and this suggests that the generation of immunological memory has been impaired, thus exposing the host to subsequent infection. The discovery that ORFV encodes an IL-10-like virokine raises the question of whether this factor adversely affects the cells that initiate the acquired immune response. We examined the… CONTINUE READING
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