Orexins stimulate steroidogenic acute regulatory protein expression through multiple signaling pathways in human adrenal H295R cells.

@article{Ramanjaneya2008OrexinsSS,
  title={Orexins stimulate steroidogenic acute regulatory protein expression through multiple signaling pathways in human adrenal H295R cells.},
  author={Manjunath Ramanjaneya and Alex C Conner and Jing Chen and Peter R. Stanfield and Harpal Randeva},
  journal={Endocrinology},
  year={2008},
  volume={149 8},
  pages={
          4106-15
        }
}
Orexins mediate a variety of physiological processes, including feeding behavior, the circadian pathway, and cortisol secretion. Steroidogenesis is regulated by a variety of neuropeptides, and one of the key rate-limiting steps is cholesterol transport across the mitochondrial membrane by the steroidogenic acute regulatory protein (StAR). StAR expression can be regulated through several different signaling pathways. Despite the clear link between orexins and steroid production, the actions of… CONTINUE READING
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