Orexins in the Regulation of the Hypothalamic-Pituitary-Adrenal Axis

@article{Spinazzi2006OrexinsIT,
  title={Orexins in the Regulation of the Hypothalamic-Pituitary-Adrenal Axis},
  author={R. Spinazzi and P. Andreis and G. Rossi and G. Nussdorfer},
  journal={Pharmacological Reviews},
  year={2006},
  volume={58},
  pages={46 - 57}
}
  • R. Spinazzi, P. Andreis, +1 author G. Nussdorfer
  • Published 2006
  • Chemistry, Medicine
  • Pharmacological Reviews
  • Orexin-A and orexin-B are hypothalamic peptides that act via two G protein-coupled receptors, named orexin type 1 and type 2 receptors (OX1-Rs and OX2-Rs). The most studied biological functions of orexins are the central control of feeding and sleep, but in the past few years findings that orexin system modulates the hypothalamic-pituitary-adrenal (HPA) axis, acting on both its central and peripheral branches, have accumulated. Orexins and their receptors are expressed in the hypothalamic… CONTINUE READING
    148 Citations
    Galanin in the regulation of the hypothalamic-pituitary-adrenal axis (Review).
    • 36
    • PDF
    Regulation of the Hypothalamic-Pituitary-Adrenal Axis
    • 248
    Regulation of the Hypothalamic-Pituitary-Adrenal Axis
    • 248
    Functions of orexins in peripheral tissues
    • 145
    Physiology of the orexinergic/hypocretinergic system: a revisit in 2012.
    • J. Kukkonen
    • Biology, Medicine
    • American journal of physiology. Cell physiology
    • 2013
    • 110
    • PDF
    Cross-talk between orexins (hypocretins) and the neuroendocrine axes (hypothalamic–pituitary axes)
    • 54
    • Highly Influenced
    • PDF

    References

    SHOWING 1-10 OF 146 REFERENCES
    Orexins stimulate corticosterone secretion of rat adrenocortical cells, through the activation of the adenylate cyclase-dependent signaling cascade
    • 128
    Orexins (hypocretins) and adrenal function.
    • 27
    Functions of the orexinergic/hypocretinergic system.
    • 258
    The Central Effects of Orexin‐A in the Hypothalamic‐Pituitary‐Adrenal Axis In Vivo and In Vitro in Male Rats
    • 112
    Prolonged orexin administration stimulates steroid-hormone secretion, acting directly on the rat adrenal gland.
    • 46
    Effects of Orexins on the Hypothalamic‐Pituitary‐Adrenal System
    • 171
    Orexin receptors are expressed in the adrenal medulla of the rat.
    • 24
    • PDF
    Food deprivation differentially modulates orexin receptor expression and signaling in rat hypothalamus and adrenal cortex.
    • 109
    • Highly Influential
    • PDF
    Expression of orexin-A and functional orexin type 2 receptors in the human adult adrenals: implications for adrenal function and energy homeostasis.
    • 152
    • PDF