Orexins in the Regulation of the Hypothalamic-Pituitary-Adrenal Axis

  title={Orexins in the Regulation of the Hypothalamic-Pituitary-Adrenal Axis},
  author={Raffaella Spinazzi and Paola G. Andreis and Gian Paolo Rossi and Gastone Giovanni Nussdorfer},
  journal={Pharmacological Reviews},
  pages={46 - 57}
Orexin-A and orexin-B are hypothalamic peptides that act via two G protein-coupled receptors, named orexin type 1 and type 2 receptors (OX1-Rs and OX2-Rs). The most studied biological functions of orexins are the central control of feeding and sleep, but in the past few years findings that orexin system modulates the hypothalamic-pituitary-adrenal (HPA) axis, acting on both its central and peripheral branches, have accumulated. Orexins and their receptors are expressed in the hypothalamic… 

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