Orexins in the Regulation of the Hypothalamic-Pituitary-Adrenal Axis
@article{Spinazzi2006OrexinsIT, title={Orexins in the Regulation of the Hypothalamic-Pituitary-Adrenal Axis}, author={R. Spinazzi and P. Andreis and G. Rossi and G. Nussdorfer}, journal={Pharmacological Reviews}, year={2006}, volume={58}, pages={46 - 57} }
Orexin-A and orexin-B are hypothalamic peptides that act via two G protein-coupled receptors, named orexin type 1 and type 2 receptors (OX1-Rs and OX2-Rs). The most studied biological functions of orexins are the central control of feeding and sleep, but in the past few years findings that orexin system modulates the hypothalamic-pituitary-adrenal (HPA) axis, acting on both its central and peripheral branches, have accumulated. Orexins and their receptors are expressed in the hypothalamic… CONTINUE READING
Paper Mentions
Blog Post
148 Citations
Leptin and the regulation of the hypothalamic-pituitary-adrenal axis.
- Biology, Medicine
- International review of cytology
- 2007
- 103
Galanin in the regulation of the hypothalamic-pituitary-adrenal axis (Review).
- Biology, Medicine
- International journal of molecular medicine
- 2007
- 36
- PDF
Orexin 2 receptor regulation of the hypothalamic–pituitary–adrenal (HPA) response to acute and repeated stress
- Psychology, Medicine
- Neuroscience
- 2017
- 24
Regulation of the Hypothalamic-Pituitary-Adrenal Axis
- Chemistry, Medicine
- Neuroimmunomodulation
- 2009
- 248
Regulation of the Hypothalamic-Pituitary-Adrenal Axis
- Chemistry, Medicine
- Neuroimmunomodulation
- 2009
- 248
Physiology of the orexinergic/hypocretinergic system: a revisit in 2012.
- Biology, Medicine
- American journal of physiology. Cell physiology
- 2013
- 110
- PDF
The hypothalamic-pituitary-adrenal axis response to stress in mice lacking functional vasopressin V1b receptors.
- Medicine
- Endocrinology
- 2007
- 114
- PDF
Cross-talk between orexins (hypocretins) and the neuroendocrine axes (hypothalamic–pituitary axes)
- Psychology, Medicine
- Frontiers in Neuroendocrinology
- 2010
- 54
- Highly Influenced
- PDF
References
SHOWING 1-10 OF 146 REFERENCES
Orexins stimulate corticosterone secretion of rat adrenocortical cells, through the activation of the adenylate cyclase-dependent signaling cascade
- Biology, Medicine
- The Journal of Steroid Biochemistry and Molecular Biology
- 1999
- 128
Orexins (hypocretins) and adrenal function.
- Chemistry, Medicine
- Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
- 2004
- 27
Functions of the orexinergic/hypocretinergic system.
- Biology, Medicine
- American journal of physiology. Cell physiology
- 2002
- 258
The Central Effects of Orexin‐A in the Hypothalamic‐Pituitary‐Adrenal Axis In Vivo and In Vitro in Male Rats
- Chemistry, Medicine
- Journal of neuroendocrinology
- 2001
- 112
Prolonged orexin administration stimulates steroid-hormone secretion, acting directly on the rat adrenal gland.
- Biology, Medicine
- International journal of molecular medicine
- 2001
- 46
Effects of Orexins on the Hypothalamic‐Pituitary‐Adrenal System
- Chemistry, Medicine
- Journal of neuroendocrinology
- 2000
- 171
Food deprivation differentially modulates orexin receptor expression and signaling in rat hypothalamus and adrenal cortex.
- Biology, Medicine
- American journal of physiology. Endocrinology and metabolism
- 2005
- 109
- Highly Influential
- PDF
Orexin A stimulates cortisol secretion from human adrenocortical cells through activation of the adenylate cyclase-dependent signaling cascade.
- Biology, Medicine
- The Journal of clinical endocrinology and metabolism
- 2001
- 121
- PDF
Expression of orexin-A and functional orexin type 2 receptors in the human adult adrenals: implications for adrenal function and energy homeostasis.
- Biology, Medicine
- The Journal of clinical endocrinology and metabolism
- 2001
- 152
- PDF