Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior

@article{Sakurai1998OrexinsAO,
  title={Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior},
  author={T. Sakurai and A. Amemiya and M. Ishii and I. Matsuzaki and R. Chemelli and H. Tanaka and S. Williams and J. Richardson and G. Kozlowski and S. Wilson and J. Arch and R. Buckingham and A. Haynes and S. Carr and R. Annan and D. Mcnulty and Wu-Schyong Liu and J. A. Terrett and N. Elshourbagy and D. Bergsma and M. Yanagisawa},
  journal={Cell},
  year={1998},
  volume={92},
  pages={573-585}
}
The hypothalamus plays a central role in the integrated control of feeding and energy homeostasis. We have identified two novel neuropeptides, both derived from the same precursor by proteolytic processing, that bind and activate two closely related (previously) orphan G protein-coupled receptors. These peptides, termed orexin-A and -B, have no significant structural similarities to known families of regulatory peptides. prepro-orexin mRNA and immunoreactive orexin-A are localized in neurons… Expand
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