Orexins/hypocretins in the ob/ob mouse: hypothalamic gene expression, peptide content and metabolic effects.

@article{StrickerKrongrad2002OrexinshypocretinsIT,
  title={Orexins/hypocretins in the ob/ob mouse: hypothalamic gene expression, peptide content and metabolic effects.},
  author={Alain Stricker-Krongrad and S{\'e}bastien Richy and Bernard Beck},
  journal={Regulatory peptides},
  year={2002},
  volume={104 1-3},
  pages={11-20}
}
Orexins (forms A and B) belong to a new family of peptides that, as neuropeptide Y (NPY), stimulate food intake when centrally injected. The ob/ob mouse is a well-characterized model of hyperphagia and obesity associated with strong metabolic disturbances and a central dysregulation of peptides involved in the control of feeding. In the present report, we investigated the hypocretin (Hcrt)/orexin (OX) peptide pathway in lean and ob/ob mice. Prepro-Hcrt/OX mRNA expression, measured by in situ… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

Similar Papers

Loading similar papers…