Orexins/hypocretins act in the posterior paraventricular thalamic nucleus during repeated stress to regulate facilitation to novel stress.

@article{Heydendael2011OrexinshypocretinsAI,
  title={Orexins/hypocretins act in the posterior paraventricular thalamic nucleus during repeated stress to regulate facilitation to novel stress.},
  author={Willem Heydendael and Kanika Sharma and Vikram S Iyer and Sandra Luz and David A Piel and Sheryl G. Beck and Seema Bhatnagar},
  journal={Endocrinology},
  year={2011},
  volume={152 12},
  pages={4738-52}
}
Orexins/hypocretins heavily innervate the posterior division of the paraventricular nucleus of the thalamus (pPVT), which expresses both orexin receptor types. The pPVT is important for adaptations to repeated stress, particularly the ability to facilitate to novel stress after repeated stress exposure. Here, we examined how orexins acting in the pPVT regulate facilitation of hypothalamic-pituitary-adrenal (HPA) responses to novel restraint after 4 d of repeated swim stress. Blockade of orexin… CONTINUE READING
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Orexin Regulation of Stress Responses Endocrinology

  • T Sakurai, A Amemiya, +14 authors Heydendael Liu
  • For personal use only. No other uses without…
  • 2011
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