Orexinergic neurons and barbiturate anesthesia.

  title={Orexinergic neurons and barbiturate anesthesia.},
  author={Tetsuya Kushikata and Kazuyoshi Hirota and Hitoshi Yoshida and Mihoko Kudo and D G Lambert and Darren Smart and Jeffrey C. Jerman and Akitomo Matsuki},
  volume={121 4},
Orexins (OXs) regulate sleep with possible interactions with brain noradrenergic neurons. In addition, noradrenergic activity affects barbiturate anesthesia. As we have also recently reported that OXs selectively evoke norepinephrine release from rat cerebrocortical slices we hypothesized that barbiturate anesthesia may result from of an interaction with… CONTINUE READING