Orexin receptors exert a neuroprotective effect in Alzheimer’s disease (AD) via heterodimerization with GPR103

@inproceedings{Davies2015OrexinRE,
  title={Orexin receptors exert a neuroprotective effect in Alzheimer’s disease (AD) via heterodimerization with GPR103},
  author={Julie Olivia Davies and Jing Chen and Ryan Charles Pink and David Christopher Mille Carter and Nigel Saunders and Georgios Sotiriadis and Belinna Bai and Yanyou Pan and David Robert Howlett and Annette Payne and Harpal Randeva and Emmanouil Karteris},
  booktitle={Scientific reports},
  year={2015}
}
Orexins are neuropeptides that regulate the sleep-wake cycle and feeding behaviour. QRFP is a newly discovered neuropeptide which exerts similar orexigenic activity, thus playing an important role in energy homeostasis and regulation of appetite. The exact expression and signalling characteristics and physiological actions of QRFP and its receptor GPR103 are poorly understood. Alzheimer's disease (AD) patients experience increased nocturnal activity, excessive daytime sleepiness, and weight… CONTINUE READING
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