Orexin receptor antagonists differ from standard sleep drugs by promoting sleep at doses that do not disrupt cognition.

@article{Uslaner2013OrexinRA,
  title={Orexin receptor antagonists differ from standard sleep drugs by promoting sleep at doses that do not disrupt cognition.},
  author={Jason M. Uslaner and Spencer J. Tye and Donnie M Eddins and Xiaohai Wang and Steven V. Fox and Alan T. Savitz and Jacquelyn Binns and Christopher E. Cannon and Susan L. Garson and Lihang Yao and Robert Hodgson and Joanne Stevens and Mark R. Bowlby and Pamela L. Tannenbaum and Joseph I Brunner and Terrence P Mcdonald and Anthony L Gotter and Scott D. Kuduk and Paul J. Coleman and Christopher J Winrow and John Renger},
  journal={Science translational medicine},
  year={2013},
  volume={5 179},
  pages={
          179ra44
        }
}
Current treatments for insomnia, such as zolpidem (Ambien) and eszopiclone (Lunesta), are γ-aminobutyric acid type A (GABAA)-positive allosteric modulators that carry a number of side effects including the potential to disrupt cognition. In an effort to develop better tolerated medicines, we have identified dual orexin 1 and 2 receptor antagonists (DORAs), which promote sleep in preclinical animal models and humans. We compare the effects of orally administered eszopiclone, zolpidem, and… CONTINUE READING

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Orexin receptor antagonists differ from standard sleep drugs by promoting sleep at doses that do not disrupt cognition

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