Orexin receptor antagonism, a new sleep-promoting paradigm: an ascending single-dose study with almorexant.

@article{Hoever2010OrexinRA,
  title={Orexin receptor antagonism, a new sleep-promoting paradigm: an ascending single-dose study with almorexant.},
  author={Petra Hoever and Sanne Lysbet de Haas and J. Winkler and Rik Schoemaker and Eleonora Chiossi and Joop van Gerven and Jasper Dingemanse},
  journal={Clinical pharmacology and therapeutics},
  year={2010},
  volume={87 5},
  pages={
          593-600
        }
}
Almorexant, a dual orexin receptor antagonist potentially representing a new class of sleep-promoting compounds, was administered in an ascending single-dose study to evaluate tolerability, pharmacokinetics, and pharmacodynamics. Seventy healthy male subjects were enrolled in this double-blind, placebo- and active-controlled study. Each dose level (1-1,000 mg) was investigated in a separate group of 10 subjects (6 on almorexant, 2 on placebo, 2 on zolpidem 10 mg). Almorexant was well tolerated… CONTINUE READING

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