Orexin neuropeptides contribute to the development and persistence of generalized avoidance behavior in the rat

@article{Viviani2014OrexinNC,
  title={Orexin neuropeptides contribute to the development and persistence of generalized avoidance behavior in the rat},
  author={Daniele Viviani and Patrizia Haegler and François Jenck and Michel Alexander Steiner},
  journal={Psychopharmacology},
  year={2014},
  volume={232},
  pages={1383-1393}
}
Avoidance of contexts directly associated with fearful experiences represents an adaptive behavioral survival strategy. Over-interpretation of contextual cues leading to generalized avoidance of situations that are only remotely similar to the original fear context represents a pathologic process that contributes to anxiety disorders. Orexin neuropeptides modulate anxiety-like behavioral and physiological responses. The objective of this paper was to investigate the impact of pharmacological… CONTINUE READING
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