Orexin neurons suppress narcolepsy via 2 distinct efferent pathways.

  title={Orexin neurons suppress narcolepsy via 2 distinct efferent pathways.},
  author={Emi Hasegawa and Masashi Yanagisawa and Takeshi Sakurai and Michihiro Mieda},
  journal={The Journal of clinical investigation},
  volume={124 2},
The loss of orexin neurons in humans is associated with the sleep disorder narcolepsy, which is characterized by excessive daytime sleepiness and cataplexy. Mice lacking orexin peptides, orexin neurons, or orexin receptors recapitulate human narcolepsy phenotypes, further highlighting a critical role for orexin signaling in the maintenance of wakefulness. Despite the known role of orexin neurons in narcolepsy, the precise neural mechanisms downstream of these neurons remain unknown. We found… CONTINUE READING
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