Orexin neurons are indispensable for stress-induced thermogenesis in mice.

@article{Zhang2010OrexinNA,
  title={Orexin neurons are indispensable for stress-induced thermogenesis in mice.},
  author={Wei Zhang and Jinko Sunanaga and Yoshiko Takahashi and Taketsugu Mori and Takeshi Sakurai and Yuichi Kanmura and Tomoyuki Kuwaki},
  journal={The Journal of physiology},
  year={2010},
  volume={588 Pt 21},
  pages={4117-29}
}
Orexin neurons contribute to cardiovascular, respiratory and analgesic components of the fight-or-flight response against stressors. Here, we examined whether the same is true for stress-induced hyperthermia. We used prepro-orexin knockout mice (ORX-KO) and orexin neuron-ablated mice (ORX-AB) in which the latter lack not only orexin, but also other putative neurotransmitter/modulators contained in the orexin neurons. In response to repetitive insertion of a temperature probe into their rectum… CONTINUE READING

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