Orexin-dependent activation of layer VIb enhances cortical network activity and integration of non-specific thalamocortical inputs

@article{Hay2014OrexindependentAO,
  title={Orexin-dependent activation of layer VIb enhances cortical network activity and integration of non-specific thalamocortical inputs},
  author={Y Audrey Hay and Sofija Andjelic and Sammy Badr and Bertrand Lambolez},
  journal={Brain Structure and Function},
  year={2014},
  volume={220},
  pages={3497-3512}
}
Neocortical layer VI is critically involved in thalamocortical activity changes during the sleep/wake cycle. It receives dense projections from thalamic nuclei sensitive to the wake-promoting neuropeptides orexins, and its deepest part, layer VIb, is the only cortical lamina reactive to orexins. This convergence of wake-promoting inputs prompted us to investigate how layer VIb can modulate cortical arousal, using patch-clamp recordings and optogenetics in rat brain slices. We found that the… CONTINUE READING