Orexin Receptor Antagonists: A New Concept In CNS Disorders?

@article{Gatfield2010OrexinRA,
  title={Orexin Receptor Antagonists: A New Concept In CNS Disorders?},
  author={John Gatfield and Catherine Brisbare-Roch and François Jenck and Christoph Boss},
  journal={ChemMedChem},
  year={2010},
  volume={5}
}
The orexin (hypocretin) system is an evolutionarily conserved neuropeptide–GPCR system functioning even in vertebrate fish. After a decade of intensive work, it appears that the orexin system plays a crucial role as homeostatic sensor of the body’s external and internal environment and regulates states of wakefulness to facilitate survival. In the brain, it acts as a central regulator of wakefulness and modulates emotional states related to, for example, stress or reward. In accordance with… 

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