Orexin A suppresses in vivo GH secretion.

  title={Orexin A suppresses in vivo GH secretion.},
  author={Luisa Mar{\'i}a Seoane and Sulay Tovar and Doguerti Perez and Federico Mallo and Miguel Lopez and Rosa Se{\~n}ar{\'i}s and Felipe F F Casanueva and Carlos Di{\'e}guez},
  journal={European journal of endocrinology},
  volume={150 5},
BACKGROUND/AIMS Orexins (OXs) are a newly described family of hypothalamic neuropeptides. Based on the distribution of OX neurons and their receptors in the brain, it has been postulated that they could play a role in the regulation of neuroendocrine function. GH secretion is markedly influenced by nutritional status and body weight. To investigate the role OX-A plays in the neuroregulation of GH secretion we have studied its effect on spontaneous GH secretion as well as GH responses to GHRH… CONTINUE READING


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