Orexin A stimulates glucose uptake, lipid accumulation and adiponectin secretion from 3T3-L1 adipocytes and isolated primary rat adipocytes

@article{Skrzypski2011OrexinAS,
  title={Orexin A stimulates glucose uptake, lipid accumulation and adiponectin secretion from 3T3-L1 adipocytes and isolated primary rat adipocytes},
  author={Marcin Skrzypski and T. T. Le and Przemyslaw Kaczmarek and Ewa Pruszynska-Oszmalek and Przemysław Pietrzak and Dawid Szczepankiewicz and Pawel Kolodziejski and Maciej Sassek and Abdullah S Arafat and Bertram Wiedenmann and Krzysztof W Nowak and Mathias Z. Strowski},
  journal={Diabetologia},
  year={2011},
  volume={54},
  pages={1841-1852}
}
Aims/hypothesisOrexin A (OXA) modulates body weight, food intake and energy expenditure. In vitro, OXA increases PPARγ (also known as PPARG) expression and inhibits lipolysis, suggesting direct regulation of lipid metabolism. Here, we characterise the metabolic effects and mechanisms of OXA action in adipocytes.MethodsIsolated rat adipocytes and differentiated murine 3T3-L1 adipocytes were exposed to OXA in the presence or absence of phosphoinositide 3-kinase (PI3K) inhibitors. Pparγ expression… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 41 REFERENCES

a potential mechanism of insulin sensitization

TP Combs, JA Wagner, agonists Berger J et al Induction of adipocyte complement-r PPARgamma
  • Endocrinology 143:998–1007 1852 Diabetologia
  • 2011
VIEW 1 EXCERPT