Orexin-A-sensitive site for energy expenditure localized in the arcuate nucleus of the hypothalamus.

@article{Wang2003OrexinAsensitiveSF,
  title={Orexin-A-sensitive site for energy expenditure localized in the arcuate nucleus of the hypothalamus.},
  author={Jian Wang and Toshimasa Osaka and Shuji Inoue},
  journal={Brain research},
  year={2003},
  volume={971 1},
  pages={128-34}
}
Orexin-A is a unique hypothalamic neuropeptide that stimulates both food intake and energy expenditure, although orexigenic peptides usually have coordinated effects on fat storage by increasing food intake and decreasing energy expenditure. Here we investigated the site of action of orexin-A-induced thermogenesis in urethane-anesthetized rats. Microinjection of 1-10 pmol orexin-A into the arcuate nucleus (Arc) specifically increased whole-body O(2) consumption (VO(2)), an index of energy… CONTINUE READING

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