Orexin A in the nucleus accumbens stimulates feeding and locomotor activity

  title={Orexin A in the nucleus accumbens stimulates feeding and locomotor activity},
  author={Andrew John Thorpe and Catherine M Kotz},
  journal={Brain Research},

Effect of Orexin-A infusion in to the Nucleus Accumbens on consummatory behaviour and alcohol preference in male Wistar rats.

Orexin-A infusion into NAcc showed significant increase in food at 1 hr in all groups compared to controls and alcohol intake and the results highlight the effect of Orexin A infusion in consummatory behaviour besides other hypothalamic and mesolimbic centres.

Effect of Orexin A antagonist (SB-334867) infusion into the nucleus accumbens on consummatory behavior and alcohol preference in Wistar rats

There was dose dependent reduction in intake of food and fluids in treated rats, which suggested a possible role for orexinergic system in ingestive behavior, however, Orexin A may not have a role in modulation of alcohol addiction by the rewarding center NAcc.

Effect of orexin-B-saporin-induced lesions of the lateral hypothalamus on performance on a progressive ratio schedule

The results indicate that OxSap lesions of the LHA disrupted food-reinforced responding on the progressive ratio schedule, and it is suggested that this disruption was brought about by a change in non-motivational (motor) processes.

Inhibition of Orexin-1/2 Receptors Disrupts Goal-Oriented Locomotor Activity During Motivated Behaviour in Male Rats

The results of this study suggest that orexin boosts goal-directed locomotor activities during sexually motivated behaviour.

Orexins in the paraventricular nucleus of the thalamus mediate anxiety-like responses in rats

This study indicates that endogenously released orexins act on the PVT to regulate anxiety levels through mechanisms involving the brain kappa and CRF receptors.

Orexins, feeding, and energy balance.




Peptides that regulate food intake: regional, metabolic, and circadian specificity of lateral hypothalamic orexin A feeding stimulation.

It is suggested that the rostral LH is the only region of the LH sensitive to the injection of OX-A, and the metabolic status of the animal at the time of injection may influence the feeding response to Ox-A.

GABA in the Nucleus Accumbens Shell Participates in the Central Regulation of Feeding Behavior

It is found that increasing local levels of GABA by administration of a selective GABA-transaminase inhibitor, γ-vinyl-GABA, elicited robust feeding in satiated rats, suggesting a physiological role for endogenous AcbSh GABA in the control of feeding.

To eat or to sleep? Orexin in the regulation of feeding and wakefulness.

These findings suggest that the orexin neuropeptide system plays a significant role in feeding and sleep-wakefulness regulation, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions.

The effect of the orexins on food intake: comparison with neuropeptide Y, melanin-concentrating hormone and galanin.

The suggestion that the orexins stimulate food intake is supported, however, this effect is weak and may cast doubt upon their physiological importance in appetite regulation in the rat.

Orexins (hypocretins) directly interact with neuropeptide Y, POMC and glucose‐responsive neurons to regulate Ca2+ signaling in a reciprocal manner to leptin: orexigenic neuronal pathways in the mediobasal hypothalamus

It is demonstrated that orexins directly regulate NPY, POMC and glucose‐responsive neurons in the ARC and VMH, in a manner reciprocal to leptin, as well as neural pathways and intracellular signaling mechanisms that may play key roles in the orexigenic action of orexlins.

Evidence of a Functional Relationship between the Nucleus Accumbens Shell and Lateral Hypothalamus Subserving the Control of Feeding Behavior

It appears that the expression of the feeding response depends on an NMDA-preferring receptor-mediated activation of LH neurons and is not the result of disinhibiting LH cells by disrupting transmission at GABA synapses.