Orexin-A depolarizes dissociated rat area postrema neurons through activation of a nonselective cationic conductance.

@article{Yang2002OrexinADD,
  title={Orexin-A depolarizes dissociated rat area postrema neurons through activation of a nonselective cationic conductance.},
  author={B J Yang and Alastair V Ferguson},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2002},
  volume={22 15},
  pages={6303-8}
}
The area postrema (AP) is involved in the regulation of body fluid balance, feeding behavior, and cardiovascular function. Orexin (ORX)-A is a 33 aa peptide that regulates energy metabolism and sympathetic and cardiovascular actions. ORX immunoreactive axons and their varicose terminals have been found in AP. In this study, whole-cell, current- or voltage-clamp recordings were obtained from 108 dissociated rat AP neurons. The mean resting membrane potential of these neurons (n = 48) was -59.24… CONTINUE READING