Orexin A decreases lipid peroxidation and apoptosis in a novel hypothalamic cell model.

  title={Orexin A decreases lipid peroxidation and apoptosis in a novel hypothalamic cell model.},
  author={Tammy A. Butterick and Joshua P. Nixon and Charles J. Billington and Catherine M. Kotz},
  journal={Neuroscience letters},
  volume={524 1},
Current data support the idea that hypothalamic neuropeptide orexin A (OxA; hypocretin 1) mediates resistance to high fat diet-induced obesity. We previously demonstrated that OxA elevates spontaneous physical activity (SPA), that rodents with high SPA have higher endogenous orexin sensitivity, and that OxA-induced SPA contributes to obesity resistance in rodents. Recent reports show that OxA can confer neuroprotection against ischemic damage, and may decrease lipid peroxidation. This is… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 16 extracted citations


Publications referenced by this paper.
Showing 1-10 of 44 references

Hypoxia - inducible factor directs POMC gene to mediate hypothalamic glucose sensing and energy balance regulation

  • G. Zhang H. Zhang, F. J. Gonzalez, S. M. Park, D. Cai
  • PLoS Biology
  • 2011

Orexin A influences lipid peroxidation and neuronal metabolic status in a novel immortalized hypothalamic cell line

  • T. A. Butterick, J. P. Nixon, C. E. Perez-Leighton, C. J. Billington, C. M. Kotz
  • Soc. Neurosci. Abstr., vol. 41, Washington, DC
  • 2011
1 Excerpt

Similar Papers

Loading similar papers…