Orexin A decreases lipid peroxidation and apoptosis in a novel hypothalamic cell model.

@article{Butterick2012OrexinAD,
  title={Orexin A decreases lipid peroxidation and apoptosis in a novel hypothalamic cell model.},
  author={Tammy A. Butterick and Joshua P. Nixon and Charles J. Billington and Catherine M. Kotz},
  journal={Neuroscience letters},
  year={2012},
  volume={524 1},
  pages={30-4}
}
Current data support the idea that hypothalamic neuropeptide orexin A (OxA; hypocretin 1) mediates resistance to high fat diet-induced obesity. We previously demonstrated that OxA elevates spontaneous physical activity (SPA), that rodents with high SPA have higher endogenous orexin sensitivity, and that OxA-induced SPA contributes to obesity resistance in rodents. Recent reports show that OxA can confer neuroprotection against ischemic damage, and may decrease lipid peroxidation. This is… CONTINUE READING

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