Orexin A activates locus coeruleus cell firing and increases arousal in the rat.

  title={Orexin A activates locus coeruleus cell firing and increases arousal in the rat.},
  author={Jim J. Hagan and Ronald A. Leslie and S M Patel and Martyn L. Evans and Trevor Anthony Kenneth Wattam and Simon Holmes and Christopher D. Benham and S. G. Taylor and Carol A. Routledge and Panida Hemmati and Richard P. Munton and Tracey E. Ashmeade and A S Shah and Jonathan P. Hatcher and Paula Hatcher and D. N. C. Jones and M. I. Smith and David C. Piper and A. Jackie Hunter and Rod A. Porter and Neil Upton},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={96 19},
  • J. Hagan, R. Leslie, N. Upton
  • Published 14 September 1999
  • Biology, Psychology
  • Proceedings of the National Academy of Sciences of the United States of America
The localization of orexin neuropeptides in the lateral hypothalamus has focused interest on their role in ingestion. The orexigenic neurones in the lateral hypothalamus, however, project widely in the brain, and thus the physiological role of orexins is likely to be complex. Here we describe an investigation of the action of orexin A in modulating the arousal state of rats by using a combination of tissue localization and electrophysiological and behavioral techniques. We show that the brain… 

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Control of arousal by the orexin neurons

Arousal effect of orexin A depends on activation of the histaminergic system

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  • 2001
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  • G. Aston-JonesF. Bloom
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1981
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