Orexin-1 receptor signaling increases motivation for cocaine-associated cues.


The orexin/hypocretin system is involved in multiple cocaine addiction processes that involve drug-associated environmental cues, including cue-induced reinstatement of extinguished cocaine seeking and expression of conditioned place preference. However, the orexin system does not play a role in several behaviors that are less cue-dependent, such as cocaine… (More)
DOI: 10.1111/ejn.12866


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