Orexin-1 receptor mediates long-term potentiation in the dentate gyrus area of freely moving rats.

@article{Akbari2011Orexin1RM,
  title={Orexin-1 receptor mediates long-term potentiation in the dentate gyrus area of freely moving rats.},
  author={Esmaeil Akbari and Fereshteh Motamedi and Farzaneh Ghiafeh Davoodi and Maryam Noorbakhshnia and Elham Ghanbarian},
  journal={Behavioural brain research},
  year={2011},
  volume={216 1},
  pages={375-80}
}
Orexin neurons, localized in the lateral hypothalamus area, synthesize two neuropeptides called orexin A and orexin B and send their axons to hippocampal formation including dentate gyrus (DG). Orexin A and orexin B act as endogenous ligands for two G-protein coupled receptors called orexin-1 and orexin-2 receptors (OX1R and OX2R). In the dentate gyrus (DG) region, OX1R, which has high affinity for orexin A, is expressed. Conflicting results have been reported regarding the effect of… CONTINUE READING