Orexin (Hypocretin) Receptor Agonists and Antagonists for Treatment of Sleep Disorders

@article{Mieda2013OrexinR,
  title={Orexin (Hypocretin) Receptor Agonists and Antagonists for Treatment of Sleep Disorders},
  author={Michihiro Mieda and Takeshi Sakurai},
  journal={CNS Drugs},
  year={2013},
  volume={27},
  pages={83-90}
}
Orexin A and orexin B are hypothalamic neuropeptides initially identified as endogenous ligands for two orphan G-protein coupled receptors (GPCRs). They play critical roles in the maintenance of wakefulness by regulating function of monoaminergic and cholinergic neurons that are implicated in the regulation of wakefulness. Loss of orexin neurons in humans is associated with narcolepsy, a sleep disorder characterized by excessive daytime sleepiness and cataplexy, further suggesting the… 

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