Orexin–Corticotropin-Releasing Factor Receptor Heteromers in the Ventral Tegmental Area as Targets for Cocaine

@article{Navarro2015OrexinCorticotropinReleasingFR,
  title={Orexin–Corticotropin-Releasing Factor Receptor Heteromers in the Ventral Tegmental Area as Targets for Cocaine},
  author={Gemma Navarro and C. Quiroz and D. Moreno-Delgado and Adam Sierakowiak and K. McDowell and E. Moreno and W. Rea and N. Cai and D. Aguinaga and L. Howell and F. Hausch and A. Cort{\'e}s and J. Mallol and V. Casad{\'o} and C. Lluis and E. Canela and S. Ferr{\'e} and P. McCormick},
  journal={The Journal of Neuroscience},
  year={2015},
  volume={35},
  pages={6639 - 6653}
}
Release of the neuropeptides corticotropin-releasing factor (CRF) and orexin-A in the ventral tegmental area (VTA) play an important role in stress-induced cocaine-seeking behavior. We provide evidence for pharmacologically significant interactions between CRF and orexin-A that depend on oligomerization of CRF1 receptor (CRF1R) and orexin OX1 receptors (OX1R). CRF1R–OX1R heteromers are the conduits of a negative crosstalk between orexin-A and CRF as demonstrated in transfected cells and rat VTA… Expand
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