Orexin/hypocretin system and autonomic control

@article{Grimaldi2014OrexinhypocretinSA,
  title={Orexin/hypocretin system and autonomic control},
  author={D. Grimaldi and A. Silvani and E. Benarroch and P. Cortelli},
  journal={Neurology},
  year={2014},
  volume={82},
  pages={271 - 278}
}
Orexins (OX-A and OX-B), also referred to as hypocretin 1 and 2, are neuropeptides synthesized by neurons located in the perifornical and lateral regions of the hypothalamus. Orexin neurons have extensive connections with the prefrontal cortex, limbic structures, hypothalamus, and brainstem, including areas involved in control of arousal, reward mechanisms, and autonomic control, and exert a primarily excitatory effect on neuronal activity via OX1 and OX2 receptors. The functions of the orexin… Expand
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