Ordering the Cytochrome c–initiated Caspase Cascade: Hierarchical Activation of Caspases-2, -3, -6, -7, -8, and -10 in a Caspase-9–dependent Manner

@article{Slee1999OrderingTC,
  title={Ordering the Cytochrome c–initiated Caspase Cascade: Hierarchical Activation of Caspases-2, -3, -6, -7, -8, and -10 in a Caspase-9–dependent Manner },
  author={Elizabeth A. Slee and Mary T. Harte and Ruth M Kluck and Beni B. Wolf and Carlos A Casiano and Donald D. Newmeyer and Hong-Gang Wang and John C. Reed and Donald W. Nicholson and Emad S. Alnemri and Douglas R Green and Seamus J. Martin},
  journal={The Journal of Cell Biology},
  year={1999},
  volume={144},
  pages={281 - 292}
}
Exit of cytochrome c from mitochondria into the cytosol has been implicated as an important step in apoptosis. In the cytosol, cytochrome c binds to the CED-4 homologue, Apaf-1, thereby triggering Apaf-1-mediated activation of caspase-9. Caspase-9 is thought to propagate the death signal by triggering other caspase activation events, the details of which remain obscure. Here, we report that six additional caspases (caspases-2, -3, -6, -7, -8, and -10) are processed in cell-free extracts in… CONTINUE READING
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