Ordering of ceramide formation, caspase activation, and Bax/Bcl-2 expression during etoposide-induced apoptosis in C6 glioma cells

@article{Sawada2000OrderingOC,
  title={Ordering of ceramide formation, caspase activation, and Bax/Bcl-2 expression during etoposide-induced apoptosis in C6 glioma cells},
  author={Motoshi Sawada and Shigeru Nakashima and Y. Banno and Haruki Yamakawa and Kanehiro Hayashi and Katsunobu Takenaka and Yasuaki Nishimura and N Sakai and Yoshinori Nozawa},
  journal={Cell Death and Differentiation},
  year={2000},
  volume={7},
  pages={761-772}
}
Etoposide (VP-16) a topoisomerase II inhibitor induces apoptosis of tumor cells. The present study was designed to elucidate the mechanisms of etoposide-induced apoptosis in C6 glioma cells. Etoposide induced increased formation of ceramide from sphingomyelin and release of mitochondrial cytochrome c followed by activation of caspase-9 and caspase-3, but… CONTINUE READING