Ordering human CD34+CD10-CD19+ pre/pro-B-cell and CD19- common lymphoid progenitor stages in two pro-B-cell development pathways.

@article{Sanz2010OrderingHC,
  title={Ordering human CD34+CD10-CD19+ pre/pro-B-cell and CD19- common lymphoid progenitor stages in two pro-B-cell development pathways.},
  author={Eva Sanz and Norman Mu{\~n}oz-A and Jorge Monserrat and Ana van-den-Rym and Pedro Escoll and Ismael Ranz and Melchor {\'A}lvarez-Mon and Antonio de-la-Hera},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 13},
  pages={5925-30}
}
Studies here respond to two long-standing questions: Are human "pre/pro-B" CD34(+)CD10(-)CD19(+) and "common lymphoid progenitor (CLP)/early-B" CD34(+)CD10(+)CD19(-) alternate precursors to "pro-B" CD34(+)CD19(+)CD10(+) cells, and do the pro-B cells that arise from these progenitors belong to the same or distinct B-cell development pathways? Using flow cytometry, gene expression profiling, and Ig V(H)-D-J(H) sequencing, we monitor the initial 10 generations of development of sorted cord blood… CONTINUE READING
Highly Cited
This paper has 42 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

Similar Papers

Loading similar papers…