Ordered restriction endonuclease maps of yeast artificial chromosomes created by optical mapping on surfaces.

@article{Cai1995OrderedRE,
  title={Ordered restriction endonuclease maps of yeast artificial chromosomes created by optical mapping on surfaces.},
  author={Wenqing Cai and Hiroyuki Aburatani and Vincent P. Stanton and David Housman and Y K Wang and David C. Schwartz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 11},
  pages={5164-8}
}
We have developed a surface mounting technology for the rapid construction of ordered restriction maps from individual DNA molecules. Optical restriction maps constructed from yeast artificial chromosome DNA molecules mounted on specially derivatized glass surfaces are accurate and reproducible, and the technology is amenable to automation. The mounting procedures described here should also be useful for fluorescence in situ hybridization studies. We believe these improvements to optical… CONTINUE READING
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