Ordered proteolysis in anaphase inactivates Plk1 to contribute to proper mitotic exit in human cells

@article{Lindon2004OrderedPI,
  title={Ordered proteolysis in anaphase inactivates Plk1 to contribute to proper mitotic exit in human cells},
  author={Catherine Lindon and Jonathon Pines},
  journal={The Journal of Cell Biology},
  year={2004},
  volume={164},
  pages={233 - 241}
}
We have found that key mitotic regulators show distinct patterns of degradation during exit from mitosis in human cells. Using a live-cell assay for proteolysis, we show that two of these regulators, polo-like kinase 1 (Plk1) and Aurora A, are degraded at different times after the anaphase-promoting complex/cyclosome (APC/C) switches from binding Cdc20 to Cdh1. Therefore, events in addition to the switch from Cdc20 to Cdh1 control the proteolysis of APC/C(Cdh1) substrates in vivo. We have… CONTINUE READING
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