Ordered mesoporous silica material SBA-15: a broad-spectrum formulation platform for poorly soluble drugs.

@article{Speybroeck2009OrderedMS,
  title={Ordered mesoporous silica material SBA-15: a broad-spectrum formulation platform for poorly soluble drugs.},
  author={Michiel van Speybroeck and Val{\'e}ry Barillaro and Thao Do Thi and Randy Mellaerts and Johan Adriaan Martens and Jan van Humbeeck and Jan Vermant and Pieter Annaert and Guy Van den Mooter and Patrick R Augustijns},
  journal={Journal of pharmaceutical sciences},
  year={2009},
  volume={98 8},
  pages={2648-58}
}
Encapsulating poorly soluble drugs in mesoporous silicates is an emerging strategy to improve drug dissolution. This study evaluates the applicability of the ordered mesoporous silicate SBA-15 as an excipient to enhance dissolution, for a test series of 10 poorly soluble compounds with a high degree of physicochemical diversity (carbamazepine, cinnarizine, danazol, diazepam, fenofibrate, griseofulvin, indomethacin, ketoconazole, nifedipine, and phenylbutazone). A generic solvent impregnation… CONTINUE READING

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