Order of assembly of human DNA repair excision nuclease.

  title={Order of assembly of human DNA repair excision nuclease.},
  author={Masahiko Wakasugi and Aziz Sancar},
  journal={The Journal of biological chemistry},
  volume={274 26},
Human excision nuclease removes DNA damage by concerted dual incisions bracketing the lesion. The dual incisions are accomplished by sequential and partly overlapping actions of six repair factors, RPA, XPA, XPC, TFIIH, XPG, and XPF.ERCC1. Of these, RPA, XPA, and XPC have specific binding affinity for damaged DNA. To learn about the role of these three proteins in damage recognition and the order of assembly of the excision nuclease, we measured the binding affinities of XPA, RPA, and XPC to a… CONTINUE READING
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