Order changes within receptor systems upon ligand binding: receptor tightening/oligomerisation and the interpretation of binding parameters.

@article{Williams2004OrderCW,
  title={Order changes within receptor systems upon ligand binding: receptor tightening/oligomerisation and the interpretation of binding parameters.},
  author={D. H. Williams and Dominic O'Brien and Alan M. Sandercock and Elaine Stephens},
  journal={Journal of molecular biology},
  year={2004},
  volume={340 2},
  pages={373-83}
}
Recent hydrogen-deuterium exchange experiments have highlighted tightening and loosening of protein structures upon ligand binding, with changes in bonding (DeltaH) and order (DeltaS) which contribute to the overall thermodynamics of ligand binding. Tightening and loosening show that ligand binding respectively stabilises or destabilises the internal structure of the protein, i.e. it shows positive or negative cooperativity between ligand binding and the receptor structure. In the case of… CONTINUE READING

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