Orchiectomy reduces susceptibility to renal ischemic injury: a role for heat shock proteins.

@article{Park2005OrchiectomyRS,
  title={Orchiectomy reduces susceptibility to renal ischemic injury: a role for heat shock proteins.},
  author={Kwon Moo Park and Hee Jung Cho and Joseph V. Bonventre},
  journal={Biochemical and biophysical research communications},
  year={2005},
  volume={328 1},
  pages={312-7}
}
In previous studies we demonstrated that the presence of testosterone, rather than the absence of estrogen, plays a critical role in gender differences in kidney ischemia/reperfusion (I/R) injury. Although molecular chaperones such as heat shock proteins (HSPs) have been implicated as protective agents in the pathophysiology of I/R injury, their roles in gender differences in susceptibility to renal I/R injury remain to be defined. Here we demonstrate that orchiectomy increases the basal and… CONTINUE READING
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