Orchidectomy of middle-aged rats decreases liver deiodinase 1 and pituitary deiodinase 2 activity.

@article{oiJurjevi2012OrchidectomyOM,
  title={Orchidectomy of middle-aged rats decreases liver deiodinase 1 and pituitary deiodinase 2 activity.},
  author={Branka T {\vS}o{\vs}i{\'c}-Jurjevi{\'c} and Branko Filipovi{\'c} and Kostja Renko and Vladimir Z. Ajd{\vz}anovi{\'c} and Milica N. Manojlovi{\'c}-Stojanoski and Verica Milo{\vs}evi{\'c} and Josef Koehrle},
  journal={The Journal of endocrinology},
  year={2012},
  volume={215 2},
  pages={247-56}
}
Endogenous androgens are involved in regulation of thyroid function and metabolism of thyroid hormones. As serum testosterone level progressively declines with age, this regulation may change. We tested how androgen deprivation, achieved by orchidectomy, affects thyroid homeostasis in middle-aged rats. Fifteen-month-old Wistar rats were orchidectomized (Orx) or sham-operated under ketamine anesthesia (15 mg/kg body weight). Five weeks after the surgery, animals were decapitated. Thyroids were… CONTINUE READING