Orchestration of lymphocyte chemotaxis by mitochondrial dynamics

  title={Orchestration of lymphocyte chemotaxis by mitochondrial dynamics},
  author={Silvia Campello and Rosa Ana Lacalle and Monica Bettella and Santos Ma{\~n}es and Luca Scorrano and Antonella Viola},
  journal={The Journal of Experimental Medicine},
  pages={2879 - 2886}
Lymphocyte traffic is required to maintain homeostasis and perform appropriate immunological reactions. To migrate into inflamed tissues, lymphocytes must acquire spatial and functional asymmetries. Mitochondria are highly dynamic organelles that distribute in the cytoplasm to meet specific cellular needs, but whether this is essential to lymphocyte functions is unknown. We show that mitochondria specifically concentrate at the uropod during lymphocyte migration by a process involving… CONTINUE READING


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