Orchestration of inflammation and adaptive immunity in Borrelia burgdorferi-induced arthritis by neutrophil-activating protein A.

@article{Codolo2013OrchestrationOI,
  title={Orchestration of inflammation and adaptive immunity in Borrelia burgdorferi-induced arthritis by neutrophil-activating protein A.},
  author={Gaia Codolo and Fleur Bossi and Paolo Durigutto and Chiara Della Bella and Fabio Fischetti and Amedeo Amedei and Francesco Saverio Tedesco and Sofia D'Elios and Marco Amedeo Cimmino and Alessandra Micheletti and Marco A Cassatella and Mario Milco D'Elios and Marina de Bernard},
  journal={Arthritis and rheumatism},
  year={2013},
  volume={65 5},
  pages={1232-42}
}
OBJECTIVE Lyme arthritis (LA) is characterized by infiltration of inflammatory cells, mainly neutrophils (polymorphonuclear cells [PMNs]) and T cells, into the joints. This study was undertaken to evaluate the role of the neutrophil-activating protein A (NapA) of Borrelia burgdorferi in eliciting inflammation and in driving the adaptive immune response. METHODS Levels of NapA, interferon-γ (IFNγ), interleukin-17 (IL-17), and T cell-attracting chemokines were assessed by enzyme-linked… CONTINUE READING
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