467 Citations
Collective timekeeping among cells of the master circadian clock.
- BiologyThe Journal of endocrinology
- 2016
This review discusses SCN organization, how intercellular communication is critical for maintaining network function, and the signaling mechanisms that play a role in this process.
A riot of rhythms: neuronal and glial circadian oscillators in the mediobasal hypothalamus
- BiologyMolecular Brain
- 2009
These results provide the first single cell resolution of endogenous circadian rhythms in clock gene expression in any intact tissue outside the SCN, reveal the cellular basis for tissue level damping in extra-SCN oscillators and demonstrate that an oscillator in the ME/PT is responsive to changes in metabolism.
In synch but not in step: Circadian clock circuits regulating plasticity in daily rhythms
- BiologyNeuroscience
- 2016
The concept of coupling in the mammalian circadian clock-network.
- BiologyJournal of molecular biology
- 2020
The central circadian clock of the suprachiasmatic nucleus as an ensemble of multiple oscillatory neurons
- BiologyNeuroscience Research
- 2020
Functional Organization of Central and Peripheral Circadian Oscillators
- Biology
- 2009
This dissertation tested the general hypothesis that the SCN has properties that distinguish it from other oscillators, thereby positioning it atop a circadian hierarchy and comparing the consequences of altering the molecular circadian clock on tissue-autonomous rhythmicity in mice.
Daily and seasonal adaptation of the circadian clock requires plasticity of the SCN neuronal network
- BiologyThe European journal of neuroscience
- 2010
The evidence that basic adaptive functions of the circadian system rely on functional plasticity in the neuronal network organization, and involve a change in phase relation among oscillatory neurons is reviewed.
Relevance of Network Organization in SCN Clock Function
- Biology
- 2015
The SCN is an especially tractable system for such queries as the function of this nucleus is known, and circadian rhythms in activity of individual cells and in the SCN as a whole can each be tracked and associated with the overall behavior and physiology of the intact animal.
References
SHOWING 1-10 OF 71 REFERENCES
Molecular analysis of mammalian circadian rhythms.
- BiologyAnnual review of physiology
- 2001
Greater understanding of the cellular and molecular mechanisms of the SCN clockwork provides opportunities for pharmacological manipulation of circadian timing.
The Biological Clock Nucleus: A Multiphasic Oscillator Network Regulated by Light
- BiologyThe Journal of Neuroscience
- 2003
The results reveal multiple phase groupings of SCN oscillators and suggest that light regulation of oscillator interactions within the SCN underlies entrainment to the photoperiod.
Cellular Construction of a Circadian Clock: Period Determination in the Suprachiasmatic Nuclei
- BiologyCell
- 1997
Synchronization of Cellular Clocks in the Suprachiasmatic Nucleus
- BiologyScience
- 2003
Real-time analysis of gene expression was used to show synchronized rhythms of clock gene transcription across hundreds of neurons within the mammalian SCN in organotypic slice culture, and Na+-dependent action potentials contributed to establishing cellular synchrony and maintaining spontaneous oscillation across the SCN.
Expression of Period Genes: Rhythmic and Nonrhythmic Compartments of the Suprachiasmatic Nucleus Pacemaker
- BiologyThe Journal of Neuroscience
- 2001
The results show that the SCN has two compartments regulating Period genes Per1, Per2, and Per3 mRNA expression differentially, and reveal the occurrence of differential regulation of clock genes in two distinctSCN regions and suggest a potential mechanism for producing functional differences in distinct SCN subregions.
Clock mutation lengthens the circadian period without damping rhythms in individual SCN neurons
- BiologyNature Neuroscience
- 2002
It is indicated that the Clock mutation lengthens the circadian period but does not abolish the circadian oscillation, and an important role of intercellular communication in the expression of circadian rhythm in the SCN is suggested.
Gates and Oscillators: A Network Model of the Brain Clock
- BiologyJournal of biological rhythms
- 2003
The authors propose a model that incorporates nonrhythmic “gate” cells and rhythmic oscillator cells with a wide range of periods, that neither requires nor excludes a role for interoscillator coupling.
Temporal and spatial expression patterns of canonical clock genes and clock‐controlled genes in the suprachiasmatic nucleus
- BiologyThe European journal of neuroscience
- 2004
The results suggest that not only is theSCN organized into light‐responsive and rhythmic regions but also that the rhythmic region of the SCN itself has an ordered arrangement of SCN oscillator cells.
The eye is necessary for a circadian rhythm in the suprachiasmatic nucleus
- BiologyNature Neuroscience
- 2003
It is found that a rhythm of phosphorylation of mitogen-activated protein (MAP) kinase in an anatomically distinct subdivision of theSCN was completely abolished by bilateral enucleation in hamsters and mice, indicating that the eye is necessary for a circadian rhythm within the SCN.
Suprachiasmatic Nucleus Grafts Restore Circadian Behavioral Rhythms of Genetically Arrhythmic Mice
- Biology, PsychologyCurrent Biology
- 2003