Orchestrating time: arrangements of the brain circadian clock

@article{Antle2005OrchestratingTA,
  title={Orchestrating time: arrangements of the brain circadian clock},
  author={M. C. Antle and R. Silver},
  journal={Trends in Neurosciences},
  year={2005},
  volume={28},
  pages={145-151}
}
Daily oscillations in physiology and behavior are regulated by a brain clock located in the suprachiasmatic nucleus (SCN). Individual cells within this nucleus contain an autonomous molecular clock. Recent discoveries that make use of new molecular and genetic data and tools highlight the conclusion that the SCN is a heterogeneous network of functionally and phenotypically differentiated cells. Neurons within SCN subregions serve distinctly separate functions in regulating the overall activity… Expand
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442 Citations
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442 Citations

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TLDR
This review discusses SCN organization, how intercellular communication is critical for maintaining network function, and the signaling mechanisms that play a role in this process. Expand
Neurobiology of Circadian Rhythm Regulation.
TLDR
The maintenance of proper coordination within this network of cellular- and tissue-level clocks is essential for health and well-being. Expand
A riot of rhythms: neuronal and glial circadian oscillators in the mediobasal hypothalamus
TLDR
These results provide the first single cell resolution of endogenous circadian rhythms in clock gene expression in any intact tissue outside the SCN, reveal the cellular basis for tissue level damping in extra-SCN oscillators and demonstrate that an oscillator in the ME/PT is responsive to changes in metabolism. Expand
In synch but not in step: Circadian clock circuits regulating plasticity in daily rhythms
TLDR
The current understanding of communication among SCN clock cells is reviewed and a collection of formal assays where changes in SCN interactions provide for plasticity in the waveform of circadian rhythms in behavior are highlighted. Expand
The central circadian clock of the suprachiasmatic nucleus as an ensemble of multiple oscillatory neurons
TLDR
The molecular, cellular, and anatomical structures of the suprachiasmatic nucleus (SCN), a network structure composed of multiple types of γ-amino butyric acid-ergic neurons and glial cells, are reviewed and recent studies aiming to understand the differential roles of multiple neuropeptide-expressing neurons in the SCN network are introduced. Expand
Circadian Gene Expression in the Suprachiasmatic Nucleus
TLDR
Circadian rhythms in mammals are orchestrated by a central clock in the suprachiasmatic nucleus (SCN) and patterns of clock gene expression within SCN cells and tissue are complex. Expand
The concept of coupling in the mammalian circadian clock-network.
TLDR
This review describes the different levels of coupling in the mammalian circadian clock system - from molecules to the whole organism and highlights recent advances in gaining knowledge of the complex organization and function of circadian network regulation. Expand
Functional Organization of Central and Peripheral Circadian Oscillators
TLDR
This dissertation tested the general hypothesis that the SCN has properties that distinguish it from other oscillators, thereby positioning it atop a circadian hierarchy and comparing the consequences of altering the molecular circadian clock on tissue-autonomous rhythmicity in mice. Expand
Comparison of clock gene expression in SCN, retina, heart, and liver of mice.
TLDR
This study examines the molecular profile of clock genes within the central SCN pacemaker and peripheral oscillators, identifying differences in phasing, amplitude, waveform, and basal expression levels. Expand
Daily and seasonal adaptation of the circadian clock requires plasticity of the SCN neuronal network
TLDR
The evidence that basic adaptive functions of the circadian system rely on functional plasticity in the neuronal network organization, and involve a change in phase relation among oscillatory neurons is reviewed. Expand
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