Orchestrated increase of dopamine and PARK mRNAs but not miR-133b in dopamine neurons in Parkinson's disease☆

@inproceedings{Schlaudraff2014OrchestratedIO,
  title={Orchestrated increase of dopamine and PARK mRNAs but not miR-133b in dopamine neurons in Parkinson's disease☆},
  author={Falk Schlaudraff and Jan Gr{\"u}ndemann and Michael Fauler and Elena Dragicevic and John Hardy and Birgit Liss},
  booktitle={Neurobiology of Aging},
  year={2014}
}
Progressive loss of substantia nigra dopamine neurons (SN DA) is a hallmark of aging and of Parkinson's disease (PD). Mutations in PARK genes cause familial PD forms. Increased expression of alpha-synuclein (PARK4) is a disease-triggering event in familial PD and also observed in SN DA neurons in sporadic PD but related transcriptional changes are unknown… CONTINUE READING