Orbitrap technology for comprehensive metabolite-based liquid chromatographic-high resolution-tandem mass spectrometric urine drug screening - exemplified for cardiovascular drugs.

@article{Helfer2015OrbitrapTF,
  title={Orbitrap technology for comprehensive metabolite-based liquid chromatographic-high resolution-tandem mass spectrometric urine drug screening - exemplified for cardiovascular drugs.},
  author={Andreas G. Helfer and Julian A Michely and A. Algora Weber and Markus R Meyer and Hans H Maurer},
  journal={Analytica chimica acta},
  year={2015},
  volume={891},
  pages={221-33}
}
LC-high resolution (HR)-MS well established in proteomics has become more and more important in bioanalysis of small molecules over the last few years. Its high selectivity and specificity provide best prerequisites for its use in broad screening approaches. Therefore, Orbitrap technology was tested for developing a general metabolite-based LC-HR-MS/MS screening approach for urinalysis of drugs necessary in clinical and forensic toxicology. After simple urine precipitation, the drugs and their… CONTINUE READING

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