Orbitofrontal dysfunction discriminates behavioral variant frontotemporal dementia from Alzheimer's disease.

@article{Hornberger2010OrbitofrontalDD,
  title={Orbitofrontal dysfunction discriminates behavioral variant frontotemporal dementia from Alzheimer's disease.},
  author={Michael Hornberger and Sharon A Savage and Sharpley Hsieh and Eneida Mioshi and Olivier Piguet and John R. Hodges},
  journal={Dementia and geriatric cognitive disorders},
  year={2010},
  volume={30 6},
  pages={547-52}
}
BACKGROUND Behavioral variant frontotemporal dementia (bvFTD) patients show prefrontal cortex dysfunction and atrophy. METHODS We investigated whether executive function in conjunction with prefrontal cortex atrophy discriminates bvFTD and Alzheimer's disease (AD) patients efficiently at presentation. RESULTS AD and bvFTD patients were distinguishable by 89.5% on their performance of 3 executive tasks: the Hayling Test of Inhibitory Control, Digit Span Backward and Letter Fluency. Similarly… CONTINUE READING

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