Orbitofrontal cortex lesions alter anxiety-related activity in the primate bed nucleus of stria terminalis.

@article{Fox2010OrbitofrontalCL,
  title={Orbitofrontal cortex lesions alter anxiety-related activity in the primate bed nucleus of stria terminalis.},
  author={Andrew S. Fox and Steven E. Shelton and Terrence R. Oakes and Alexander K. Converse and Richard J. Davidson and Ned H. Kalin},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2010},
  volume={30 20},
  pages={
          7023-7
        }
}
In children, behavioral inhibition (BI) in response to potential threat predicts the development of anxiety and affective disorders, and primate lesion studies suggest involvement of the orbitofrontal cortex (OFC) in mediating BI. Lesion studies are essential for establishing causality in brain-behavior relationships, but should be interpreted cautiously because the impact of a discrete lesion on a complex neural circuit extends beyond the lesion location. Complementary functional imaging… CONTINUE READING

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