Orbitofrontal activation restores insight lost after cocaine use

  title={Orbitofrontal activation restores insight lost after cocaine
  author={Federica Lucantonio and Yuji Takahashi and Alexander F Hoffman and Chun Yun Chang and Sheena Chaudhary and Yavin Shaham and Carl R. Lupica and Geoffrey Schoenbaum},
  booktitle={Nature Neuroscience},
Addiction is characterized by a lack of insight into the likely outcomes of one's behavior. Insight, or the ability to imagine outcomes, is evident when outcomes have not been directly experienced. Using this concept, work in both rats and humans has recently identified neural correlates of insight in the medial and orbital prefrontal cortices. We found that these correlates were selectively abolished in rats by cocaine self-administration. Their abolition was associated with behavioral… CONTINUE READING
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