Orb and a long poly(A) tail are required for efficient oskar translation at the posterior pole of the Drosophila oocyte.

@article{Castagnetti2003OrbAA,
  title={Orb and a long poly(A) tail are required for efficient oskar translation at the posterior pole of the Drosophila oocyte.},
  author={Stefania Castagnetti and Anne Ephrussi},
  journal={Development},
  year={2003},
  volume={130 5},
  pages={835-43}
}
During Drosophila oogenesis, the posterior determinant, Oskar, is tightly localized at the posterior pole of the oocyte. The exclusive accumulation of Oskar at this site is ensured by localization-dependent translation of oskar mRNA: translation of oskar mRNA is repressed during transport and activated upon localization at the posterior cortex. Previous studies have suggested that oskar translation is poly(A)-independent. We show that a long poly(A) tail is required for efficient oskar… CONTINUE READING
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Analysis of RNA distribution during Drosophila oogenesis using fluorescent in situ hybridization

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